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Helisterculins A and B, Two New (7.5′,8.2′)-Neolignans, and Helisorin, the First (6.4′,7.5′,8.2′)-Neolignan, from the Indonesian Medicinal Plant Helicteres isora

✍ Scribed by Yasuhiro Tezuka; Masataka Terazono; Tomoco I. Kusumoto; Yukiko Kawashima; Yasumaru Hatanaka; Shigetoshi Kadota; Masao Hattori; Tsuneo Namba; Tohru Kikuchi; Ken Tanaka; Sutardjo Supriyatna

Publisher
John Wiley and Sons
Year
1999
Tongue
German
Weight
140 KB
Volume
82
Category
Article
ISSN
0018-019X

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✦ Synopsis

During a chemical study of Indonesian medicinal plants, we examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines. From a water extract of the fruits, we isolated three new neolignans, helisterculins A (1) and B (2) and helisorin (3), and elucidated their structures by spectral analyses. Helisterculins A (1) and B (2) are (7.5',8.2')-neolignans with a bicyclo[2.2.2]octene C-framework, while helisorin ( 3) is a (6.4',7.5',8.2')-neolignan with a very rare 4,4a,9,9a-tetrahydro-3,9-methano-3H-fluorene Cframework. The natural product with the latter C-framework has no literature precedent. The neolignans 1 ± 3 showed weak inhibitory activity against reverse transcriptase from avian myeloblastosis virus.

📜 SIMILAR VOLUMES

ChemInform Abstract: Helicterins A—F, Si
ChemInform Abstract: Helicterins A—F, Six New Dimeric (7.5′,8.2′)-Neolignans from the Indonesian Medicinal Plant Helicteres isora.
✍ Yasuhiro Tezuka; Masataka Terazono; Tomoco I. Kusumoto; Yasumaru Hatanaka; Shige 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

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