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Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF

✍ Scribed by C Wallasch; J.E Crabtree; D Bevec; P.A Robinson; H Wagner; A Ullrich

Book ID: 117052212
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 268 KB
Volume: 295
Category: Article
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(02)00740-4

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## Abstract Several agonists acting on G protein‐coupled receptors (GPCR) enhance the mitogenic effect of epidermal growth factor (EGF) in rat hepatocytes, through mechanisms that have only partially been clarified. Results in various cells have led to the idea that a major mechanism for GPCR‐media