Helicobacter pylori infection promotes methylation of WWOX gene in human gastric cancer
β Scribed by Jiaqin Yan; Mingzhi Zhang; Junhui Zhang; Xiaobing Chen; Xudong Zhang
- Book ID
- 116301640
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 408 KB
- Volume
- 408
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Aberrant DNA methylation is deeply involved in human cancers, but its inducers and targets are still mostly unclear. __Helicobacter pylori__ infection was recently shown to induce aberrant methylation in gastric mucosae, and produce a predisposed field for cancerization. Here, we analyz
## Abstract To study the status of oxidative DNA damage in __Helicobacter pylori__ infection in more detail, we examined oxidative DNA damage to individual genes by determining the loss of PCR product of a targeted gene before and after gastric mucosal DNA was treated with 8βhydroxyguanine glycosyl