Helicobacter pylori infection is not associated with increased risk of colorectal polyps in Taiwanese

✍ Scribed by Jyh-Ming Liou; Jou-Wei Lin; Shih-Pei Huang; Jaw-Town Lin; Ming-Shiang Wu

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: French
• Weight: 47 KB
• Volume: 119
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.22050

✦ Synopsis

Dear Sir,

A recent report by Mizuno et al. 1 showed that Helicobacter pylori (H. pylori) infection was associated with increased risk of colorectal adenomatous polyps in Japanese. The prevalence of tubular adenoma were 42.4% and 18.9% in H. pylori infected and noninfected patients, respectively. 1 We read that article with great interest and examined the relationships between H. pylori infection and colorectal polyps in Taiwanese. Asymptomatic individuals who underwent colonoscopy, esophagogastroduodenoscopy and 13 C-urea breath test ( 13 C-UBT) as part of health check-up were enrolled for analysis. 13 C-UBT was performed with infrared spectrometer, which has the sensitivity of 97.8%, specificity of 96.8% and accuracy of 97.5%. 2 Polyethylene glycol lavage solution (Klean-Prep; Norgine Limited, Harefield, Middlesex, UK), followed by glycerin enema were used for bowel preparation.

Colonoscopy was performed by one of 7 board-certified gastroenterologists who had performed at least 500 colonoscopies using a standard colonoscope (CF-240AI; Olympus Optical Co, Tokyo, Japan). Chromoendoscopy with 0.2% indigo carmine was applied to all detected polypoid lesions for a more detailed assessment and description of colonoscopic morphology. Larger (>0.5 cm) polyps were removed with standard polypectomy snares whereas smaller (<0.5 cm) polyps were removed with a biopsy forceps. The criteria recommended by World Health Organization were used to classify the polyps. 3 Advanced colonic neoplasm was defined as meeting any one of the following features: (1) an adenoma greater than 10 mm in diameter; (2) an adenoma containing villous architecture greater than 20%; (3) an adenoma with severe dysplasia or (4) invasive cancer. For analyses, findings such as juvenile or inflammatory polyps, lipomas, lymphoid aggregates and chronic nonspecific inflammation were regarded as normal mucosa. 1 Values in parentheses indicate percentages.