Helicobacter pylori: Basic Mechanisms to Clinical Cure

✍ Scribed by J. G. Fox (auth.), Richard H. Hunt, Guido N. J. Tytgat (eds.)

• Publisher: Springer Netherlands
• Year: 1994
• Tongue: English
• Leaves: 618
• Edition: 1
• Category: Library

✦ Synopsis

Helicobacter pylori has attracted widening interest from basic scientists and clinical investigators and the information on this organism is increasing exponentially. It is now accepted that H.Pylori is the most important cause of chronic active gastritis. Furthermore, data have confirmed a marked reduction in the relapse rate of both duodenal and gastric ulcer after eradication of the organism. These important clinical observations have served as a strong stimulus to the investigation of the basic mechanisms involved in the pathogenesis of H. pylori-associated inflammation and the subsequent alterations of gastroduodenal function and gastric mucosal architecture.
The book contains chapters by a multidisciplinary, international group of basic scientists and clinical investigators who focus on various microbiological aspects of H. pylori, on the role of H. pylori in peptic ulcer and gastric cancer, and the current status of therapy.
The book contains the proceedings of the conference on `Helicobacter pylori: Basic Mechanisms to Clinical Cure', held at Amelia Island, Florida, U.S.A., on November 3--6, 1993.

✦ Table of Contents

Front Matter....Pages i-xix
Front Matter....Pages 1-1
In vivo models of gastric Helicobacter infections....Pages 3-27
H. pylori species heterogeneity....Pages 28-40
H. pylori urease....Pages 41-58
Basic bacteriology of H. pylori : H. pylori colonization factors....Pages 59-72
Front Matter....Pages 73-73
Epidemiology of H. pylori in Western countries....Pages 75-84
H. pylori in developing countries....Pages 85-94
Prevalence/disease correlates of H. pylori ....Pages 95-112
Reinfection with H. pylori ....Pages 113-120
Front Matter....Pages 121-121
Breakdown of the mucus layer by H. pylori ....Pages 123-138
Decreased hydrophobicity of gastroduodenal mucosa due to H. pylori infection in humans....Pages 139-147
Adherence and internalization of H. pylori by epithelial cells....Pages 148-162
Mechanisms of ammonia-induced gastric mucosal injury: role of glutathione and cysteine proteases....Pages 163-168
Lipopolysaccharide (LPS)-related damage by H. pylori ....Pages 169-179
The cpn60 heat shock protein homologue of H. pylori ....Pages 180-187
Gastric mucosal injury: interactions of mast cells, cytokines and nitric oxide....Pages 188-197
H. pylori supernatant contains a novel chemotactic factor for monocytes different from FMLP....Pages 198-206
H. pylori -induced neutrophil activation and production of toxic oxygen radicals....Pages 207-213
Polymorphonuclear leukocytes traffic into the gastric mucosa and through the gastric mucosal barrier in H. pylori infection: is that bad?....Pages 214-221
H. pylori vacuolating toxin....Pages 222-231
H. pylori alcohol dehydrogenase....Pages 232-242
Front Matter....Pages 243-243
Effect of H. pylori infection on gastrin and gastric acid secretion....Pages 245-256
H. pylori , gastrin and somatostatin....Pages 257-266
Parietal cell responsiveness in H. pylori infections....Pages 267-272
Role of bacterial amines in H. pylori -associated hypergastrinaemia....Pages 273-280
Do gastric mucosal nerves remodel in H. pylori gastritis?....Pages 281-291
Front Matter....Pages 293-293
Overview of the immune response to H. pylori ....Pages 295-305
Specific H. pylori immune response....Pages 306-308
B cell responses in H. pylori infection....Pages 309-320
T cell subsets in H. pylori -associated gastritis....Pages 321-332
Down-regulation of the immune response to H. pylori ....Pages 333-341
The clinical value of a saliva diagnostic assay for antibody to H. pylori ....Pages 342-350
Front Matter....Pages 351-351
Spectrum and implications of inflammation with H. pylori ....Pages 353-361
‘Hypertrophic’ gastritis in H. pylori infection....Pages 362-371
Long-term consequences of H. pylori infection: time trends in H. pylori gastritis, gastric cancer and peptic ulcer disease....Pages 372-380
Determinants of gastritis phenotype in H. pylori infection....Pages 381-389
The ulcer-associated cell lineage (UACL); a newly recognized pathway of gastrointestinal differentiation of importance in the natural healing of peptic ulcer disease....Pages 390-404
Front Matter....Pages 405-405
Acute infection with H. pylori ....Pages 407-412
H. pylori in asymptomatic people....Pages 413-420
Determinants of clinical outcome of H. pylori infection: duodenal ulcer....Pages 421-428
H. pylori and gastric ulcer disease....Pages 429-436
Front Matter....Pages 405-405
Functional dyspepsia and H. pylori : a controversial link....Pages 437-448
H. pylori and NSAIDs: a meta-analysis on interactions of acute gastroduodenal injury, gastric and duodenal ulcers and upper gastrointestinal symptoms....Pages 449-457
Front Matter....Pages 459-459
H. pylori and gastric cancer: the significance of the problem....Pages 461-468
The ascorbic acid story....Pages 469-474
Role of bacterial overgrowth in gastric carcinogenesis....Pages 475-482
The role of PCR techniques in the epidemiology of H. pylori infections....Pages 483-489
Role of H. pylori in atrophic gastritis and intestinal metaplasia....Pages 490-497
H. pylori -associated gastric lymphoma....Pages 498-503
Animal models for Helicobacter -induced gastric and hepatic cancer....Pages 504-522
Flaws in H. pylori -related carcinogenesis hypothesis....Pages 523-528
Front Matter....Pages 529-529
Determinants of antimicrobial effectiveness in H. pylori gastritis....Pages 531-537
Mucosal antibiotic levels....Pages 538-549
H. pylori eradication....Pages 550-569
H. pylori resistance to antibiotics....Pages 570-583
The role of acid suppression in the treatment of H. pylori infection....Pages 584-592
Prospects for vaccination against H. pylori infection....Pages 593-599
Back Matter....Pages 601-612

✦ Subjects

Gastroenterology; Infectious Diseases; Pharmacology/Toxicology