Helical Structure of Dermaseptin B2 in a Membrane-Mimetic Environment
✍ Scribed by Lequin, Olivier; Bruston, Francine; Convert, Odile; Chassaing, Gérard; Nicolas, Pierre
- Book ID
- 115498232
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 287 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0006-2960
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The 32 amino acid hormone human calcitonin was studied at pH 3.7 and 7.4 by multidimensional NMR spectroscopy in sodium dodecyl sulfate micelles at 310K. The secondary structure was obtained from nuclear Overhauser enhancement spectroscopy (NOESY), 3 J HN␣ coupling constants, and slowly exchanging a
## Abstract Dermaseptins, small polycationic peptides synthesized by amphibians, exert a lytic action on bacteria, protozoa, yeast, and filamentous fungi at micromolar concentrations, but unlike polylysines, show little hemolytic activity. Dermaseptins S are active only against bacteria and form ag