## Abstract The amebicidal activity of the phenanthroline quinones published earlier^2^) and of their derivates described in this paper is discussed. The highest activity was found with 4,7‐phenanthrolino‐5, 6‐ quinone **1** and its monosemicarbazone **3**, which are also active in man. Further der
Heilmittelchemische Studien in der heterocyclischen Reihe. 31. Mitteilung. Benzo-1,2,3-thiadiazine mit hypotensiver und diuretischer Wirkung
✍ Scribed by P. Schmidt; K. Eichenberger; M. Wilhelm
- Publisher
- John Wiley and Sons
- Year
- 1962
- Tongue
- German
- Weight
- 236 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The synthesis of 4‐hydrazino‐benzo‐1,2,3‐thiadiazine 1,1‐dioxides is described. Chemical reactions and properties of these compounds are discussed. Some of the derivatives show hypotensive as well as diuretic activity.
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## Abstract The analgetic activity of 1,3,4‐trimethyl‐5‐cyano‐pyridazone‐(6) (I), a compound chemically similar to the pyridine‐alkaloid ricinine is discussed. Many similar derivatives have been prepared, but only pyridazones having in position 5 a cyano, in 3 and 4 alkyl, and in 1 a methyl group h
## Abstract 1‐Methyl‐3‐cyano‐l, 6‐dihydro‐pyridine (III) was allowed to react under mild conditions with maleic anhydride. After acid hydrolysis of the resulting adduct IV, followed by esterification of the dicarboxylic acid V, 2‐methyl‐5,6‐dicarbomethoxy‐7‐cyano‐2‐aza‐bicyclo[2.2.2]octene‐(7) (VI)