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Heilmittelchemische Studien in der heterocyclischen Reihe. 24. Mitteilung. Über die Umlagerung heterocyclischer N-Oxyde mit Trifluor-acetanhydrid

✍ Scribed by H. U. Daeniker; J. Druey

Publisher: John Wiley and Sons
Year: 1958
Tongue: German
Weight: 554 KB
Volume: 41
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19580410723

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✦ Synopsis

Abstract

Trifluoroacetic anhydride is a mild reagent for specifically rearranging heterocyclic N‐oxides to the corresponding nuclear oxygenated heterocycles. 2‐Cyanoquinol‐4‐one is thus obtained from 2‐cyanoquinoline N‐oxide, while two products are formed from 4‐cyanoquinoline N‐oxide, namely 4‐cyanoquinol‐2‐one, and 3‐hydroxy‐4‐cyanoquinoline. The structures of the new compounds have been confirmed by degradation.

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Heilmittelchemische Studien in der heterocyclischen Reihe. 20. Mitteilung. Über die Herstellung von 2-Phenyl-3-amino-pyrazol als Aminokomponente eines langwirkenden Sulfonamids

✍ P. Schmidt; J. Druey 📂 Article 📅 1958 🏛 John Wiley and Sons 🌐 German ⚖ 240 KB 👁 1 views

## Abstract Convenient methods to obtain 2‐phenyl‐3‐amino‐pyrazole, a compound not reported in the literature, are described. The substance is the aminocomponent of a sulfonamide with an outstanding chemotherapeutic effect.