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Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis

✍ Scribed by Tran, S E F; Meinander, A; Holmström, T H; Rivero-Müller, A; Heiskanen, K M; Linnau, E K; Courtney, M J; Mosser, D D; Sistonen, L; Eriksson, J E


Book ID
110016602
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
294 KB
Volume
10
Category
Article
ISSN
1350-9047

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Down-regulation of FLIP sensitizes rheum
✍ Guillermo Palao; Begoña Santiago; María Galindo; Mónica Payá; Juan C. Ramirez; J 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB

## Abstract ## Objective Hyperplasia of fibroblast‐like synoviocytes (FLS) contributes to chronic inflammation and joint destruction in rheumatoid arthritis (RA). FLICE‐inhibitory protein (FLIP) is an antiapoptotic protein that might prevent apoptotic elimination of FLS in response to death ligand