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Heat-shock responsive elements in the induction of the multidrug resistance gene (MDR1)

✍ Scribed by Noriyuki Kioka; Yoshiaki Yamano; Tohru Komano; Kazumitsu Ueda

Book ID
115925900
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
412 KB
Volume
301
Category
Article
ISSN
0014-5793

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The most consistantly reported alteration of multidrug-resistant carcinoma cells is the overexpression of a membrane glycoprotein, termed P-glycoprotein. In this study we examined whether the strong intrinsic chemotherapy resistance of glial tumors might be related to the expression of the MDR1 gene