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Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation

✍ Scribed by Westerheide, S. D.; Morimoto, R. I.

Book ID
125518136
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2005
Tongue
English
Weight
700 KB
Volume
280
Category
Article
ISSN
0021-9258

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The heat shock response is a well-conserved defence mechanism against the accumulation of misfolded proteins due to prolonged elevated heat. The cell responds to heat shock by raising the levels of heat shock proteins (hsp), which are responsible for chaperoning protein refolding. The synthesis of h