Heat shock protein 70 kDa over-expression and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigrostriatal degeneration in mice
✍ Scribed by L. Gao; J. Díaz-Martín; W.H. Dillmann; J. López-Barneo
- Book ID
- 116789497
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 1001 KB
- Volume
- 193
- Category
- Article
- ISSN
- 0306-4522
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## Abstract Administration of the neurotoxicant 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) to C57BL/6 mice targets nigrostriatal dopaminergic neurons, leading to cell death and the depletion of striatal dopamine. After MPTP lesioning in young adult mice, surviving nigrostriatal dopaminergi
Previous studies have suggested a role for the retrograde messenger, nitric oxide (NO), in methamphetamine (METH)-and 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Since evidence supported the involvement of the neuronal nitric oxide synthase (nNOS) isoform i