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Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1

✍ Scribed by Khaleque, M A; Bharti, A; Gong, J; Gray, P J; Sachdev, V; Ciocca, D R; Stati, A; Fanelli, M; Calderwood, S K

Book ID
110072820
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
329 KB
Volume
27
Category
Article
ISSN
0950-9232

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Activation of the heat-shock or stress response is generally considered a cytoprotective response to heat or other proteotoxic stresses. In mammalian cells, stressinduced transcription of heat-shock genes is regulated by heat-shock transcription factor 1 (HSF1). We now show that activation of the Fa