HEAT repeats in the Huntington's disease protein
β Scribed by Andrade, Miguel A.; Bork, Peer
- Book ID
- 109918257
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 418 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1061-4036
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## Abstract Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by an abnormal expansion of a polymorphic stretch of CAG repeats in the coding 5β² part of the __HD__ gene on chromosome 4p. Expansions of CAG blocks beyond 35 repeats are associated with the
Huntington's disease (HD) is a neurodegenerative disorder associated with expansion of CAG trinucleotide repeats in the huntingtin gene. A minimum of 36 CAG repeats is usually reported in patients with clinical features of HD; 30 to 35 repeats represent an intermediate range. Here we report a 65-yea