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Heat capacities of transfer of some amino acids and peptides from water to aqueous urea solution

✍ Scribed by K. P. Prasad; J. C. Ahluwalia

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
472 KB
Volume
19
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Integral enthalpies of solution at low concentrations of several amino acids and peptides in 2 and 6__M__ urea solutions have been determined at 25 and 35°C. These data have been used to derive the enthalpies of transfer (at 25 and 35°C) and heat capacities of transfer (at 30°C) of these amino acids and peptides from water to aqueous urea solutions. Furthermore, the enthalpies of transfer and heat capacities of transfer per CH~2~ group and per peptide group CONH have also been estimated. These results show that while the enthalpies and heat capacities of transfer per CH~2~ group are positive and negative, respectively, the reverse is true for CONH group. The implications of these results in the mechanism of the denaturation of proteins by urea are discussed.

📜 SIMILAR VOLUMES

Partial molar volumes of the amino acid
Partial molar volumes of the amino acid side-chains of proteins in aqueous solution: Some comments on their estimation using partial molar volumes of amino acids and small peptides
✍ Gavin R. Hedwig 📂 Article 📅 1992 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 317 KB 👁 1 views

using partial molar volume data, V t , in aqueous solution at 25°C for some peptides of sequence Gly-X-Gly, where X is an amino acid. These side-chain partial molar volumes are critically compared with those obtained using V data for amino acids. It is concluded that side-chain partial molar volumes