Heart valve tissue engineering
โ Scribed by Stefan Neuenschwander; Simon P. Hoerstrup
- Book ID
- 116939903
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 767 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0966-3274
No coin nor oath required. For personal study only.
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Tissue engineered lamb heart valve leaflets ( N -3) were constructed by repeatedly seeding a concentrated suspension of autologous myofibroblasts onto a biodegradable synthetic polymeric scaffold composed of fibers made from polyglycolic acid and polylactic acid. Over a 2-week period the cells attac
## Abstract Heart valve disease is a significant cause of mortality worldwide. However, to date, a nonthrombogenic, noncalcific prosthetic, which maintains normal valve mechanical properties and hemodynamic flow, and exhibits sufficient fatigue properties has not been designed. Current prosthetic d