## Abstract Heart valve disease is a significant cause of mortality worldwide. However, to date, a nonthrombogenic, noncalcific prosthetic, which maintains normal valve mechanical properties and hemodynamic flow, and exhibits sufficient fatigue properties has not been designed. Current prosthetic d
Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges
β Scribed by Karen Mendelson; Frederick J. Schoen
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 499 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0090-6964
No coin nor oath required. For personal study only.
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Tissue engineered lamb heart valve leaflets ( N -3) were constructed by repeatedly seeding a concentrated suspension of autologous myofibroblasts onto a biodegradable synthetic polymeric scaffold composed of fibers made from polyglycolic acid and polylactic acid. Over a 2-week period the cells attac
## Abstract Bovine pericardium has been extensively applied as the biomaterial for artificial heart valves and may potentially be used as a scaffold for tissueβengineered heart valves after decellularization. Although various methods of decellularization are currently available, it is unknown which