Heart rate response to standing as an index of adaptation to imipramine during treatment of panic disorder
✍ Scribed by H. C. Middleton; D. J. Nutt
- Book ID
- 102265332
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 285 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
The heart rate and blood pressure response to standing in eight patients receiving imipramine treatment for panic disorder were compared with the same measures in eight normal subjects after a single large dose. Despite higher plasma drug levels, patients on long-term medication had a less abnormal orthostatic response than volunteers. This suggests that the heart rate response to standing could be a useful index of the neuropharmacological adaptation known to occur during administration of therapeutic doses of tricyclic antidepressant. KEY worn-Imipramine, panic disorder, orthostatic reflex, neuropharmacological adaptation.