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Heart disease linked to oestrogen-receptor gene methylation

✍ Scribed by Janet Fricker

Book ID
114382493
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
33 KB
Volume
5
Category
Article
ISSN
1357-4310

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πŸ“œ SIMILAR VOLUMES

Methylation of the oestrogen receptor Cp
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
✍ Issa, Jean-Pierre J.; Ottaviano, Yvonne L.; Celano, Paul; Hamilton, Stanley R.; πŸ“‚ Article πŸ“… 1994 πŸ› Nature Publishing Group 🌐 English βš– 571 KB

We report that CpG island methylation, an epigenetic modification of DNA known to correlate closely with silencing of gene transcription, appears in the oestrogen receptor (ER) gene in a subpopulation of cells which increases as a direct function of age in human colonic mucosa. This same methylation