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Health-related quality of life in patients with Gilles de la Tourette's syndrome

✍ Scribed by Kirsten Müller-Vahl; Ines Dodel; Norbert Müller; Alexander Münchau; Jens Peter Reese; Monika Balzer-Geldsetzer; Richard Dodel; Wolfgang H. Oertel

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
121 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

To investigate the health‐related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 ± 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi‐structured, self‐rating interview. HrQoL was measured using the EQ‐5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette‐syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self‐care (6.6%). The mean EQ‐5D visual analog scale (EQ‐VAS) was 65.4 ± 21.9. The patients had a mean BDI score of 12.3 ± 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 ± 5.2. The mean STSSS value was 3.2 ± 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R^2^ = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co‐morbidities such as depression should be diagnosed and treated vigorously. © 2009 Movement Disorder Society

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