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Healing of colonic anastomoses after immediate postoperative intraperitoneal administration of oxaliplatin

✍ Scribed by Dimitrios Kanellos; Manousos-Georgios Pramateftakis; Haralampos Demetriades; Emmanouil Zacharakis; Stamatios Angelopoulos; Ioannis Mantzoros; Ioannis Kanellos; Kalliopi Despoudi; Thomas Zaraboukas; Georgios Koliakos; Kalliopi Galovatsea; Haralampos Lazaridis

Publisher: Springer
Year: 2008
Tongue: English
Weight: 133 KB
Volume: 23
Category: Article
ISSN: 0179-1958
DOI: 10.1007/s00384-008-0538-5

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## Abstract To study the effects of preoperative radiochemotherapy (RCT) on the healing of colonic anastomosis, the rectosigmoid colon in male Wistar rats was irradiated up to an end dose of 41.6 Gy (RT) or sham‐irradiated (SR). During the last 5 days of the irradiation schedule, 5‐fluorouracil (5‐