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Head and neck mucosal melanoma: Experience with 42 patients, with emphasis on the role of postoperative radiotherapy

✍ Scribed by Marco Meleti; C. René Leemans; Remco de Bree; Paolo Vescovi; Enrico Sesenna; Isaäc van der Waal

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
168 KB
Volume
30
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

Treatment of head and neck mucosal melanoma remains a challenge. Surgery has traditionally been the main therapeutic approach. The role of postoperative radiotherapy has never been clearly established.

Methods.

The experience with a group of 42 patients (16 males, 26 females) with a primary head and neck mucosal melanoma is reported.

Results.

Eleven of 19 patients (57.9%) receiving surgery alone developed a regional lymphatic metastasis. For patients receiving postoperative radiotherapy (19 patients), regional metastatic spread occurred in 4 patients (21%). Percentages of local failure were 57.9% (11/19) and 26.3% (5/19) for patients treated with surgery alone and for those treated with surgery and radiotherapy, respectively. Distant metastases occurred in 10 of 19 patients (52.6%) receiving surgery alone and in 9 of 19 patients (47.3%) receiving both therapies.

Conclusions.

The present evaluation confirms a poor prognosis for patients with head and neck mucosal melanoma, independent of the treatment modality. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

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