HDM2 overexpression and focal loss of p14/ARF expression may deregulate the p53 tumour suppressor pathway in meningeal haemangiopericytomas. Study by double immunofluorescence and laser scanning confocal microscopy

Retinoblastoma (Rb) tumor-suppressor pat

Retinoblastoma (Rb) tumor-suppressor pathway alterations in meningeal hemangiopericytomas: High E2F transcription factor 1 expression and loss of Rb expression : Study by double immunofluorescence staining and laser-scanning confocal microscopy

✍ Juan-Carlos Martinez; Julio-Cesar Palomino; Rafael Samaniego; Juan M. Sepulveda; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB

## Abstract ## BACKGROUND. The authors analyzed the retinoblastoma (Rb) tumor‐suppressor pathway in meningeal hemangiopericytomas (MHPCs). ## METHODS. Immunohistochemical detection of the Rb pathway proteins (Rb; E2F transcription factor 1 [E2F1]; cyclins D1, D3, and E; cyclin‐dependent kinase 4