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HDACs link the DNA damage response, processing of double-strand breaks and autophagy

✍ Scribed by Robert, Thomas; Vanoli, Fabio; Chiolo, Irene; Shubassi, Ghadeer; Bernstein, Kara A.; Rothstein, Rodney; Botrugno, Oronza A.; Parazzoli, Dario; Oldani, Amanda; Minucci, Saverio


Book ID
109900408
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
719 KB
Volume
471
Category
Article
ISSN
0028-0836

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## Abstract DNA double‐strand breaks (DSBs) are the most hazardous lesions arising in the genome of eukaryotic organisms, and yet occur normally during DNA replication, meiosis, and immune system development. The efficient repair of DSBs is crucial in maintaining genomic integrity, cellular viabili