HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer

Expression of the ULBP ligands for NKG2D

Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC

✍ Atsushi Inagaki; Takashi Ishida; Hiroki Yano; Toshihiko Ishii; Shigeru Kusumoto; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 432 KB

## Abstract Antibody‐dependent cellular cytotoxicity (ADCC) is a major antitumor mechanism of action of therapeutic monoclonal antibodies (mAbs). The aim of this study was to identify tumor‐associated factors which determine susceptibility to rituximab‐induced ADCC. Thirty different CD20+ non‐Hodgk