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HCO3−-coupled Na+influx is a major determinant of Na+turnover and Na+/K+pump activity in rat hepatocytes

✍ Scribed by J. Gregory Fitz; Steven D. Lidofsky; Richard A. Weisiger; Ming-Hong Xie; Mary Cochran; Thomas Grotmol; Bruce F. Scharschmidt


Publisher
Springer
Year
1991
Tongue
English
Weight
963 KB
Volume
122
Category
Article
ISSN
0022-2631

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Treatment of Friend-erythroleukemia cells with 1.5% dimethylsulfoxide (DMSO) caused a decrease in ouabain sensitive 86Rb+-uptake beginning six to seven hours after DMSO addition indicating a reduced function of the Na+, K+-pump. However, analysis of the ouabain sensitive 86Rb+-uptake after Na+-prelo