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Hbv-Dna hybridization in hepatocellular carcinoma associated with alcohol in japan

✍ Scribed by Dr. Norio Horiike; Kojiro Michitaka; Morikazu Onji; Toshiko Murota; Yasuyuki Ohta

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 491 KB
Volume: 28
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890280315

No coin nor oath required. For personal study only.

✦ Synopsis

To clarify the role of the hepatitis B virus (HBV) in hepatocellular carcinoma (HCC) associated with alcohol consumption, HBV-DNA in the liver of 19 patients with HCC were investigated. HBV-DNA was examined by Southern blot hybridization. HBV-DNA was integrated into tumor cells from five out of six (83%) patients with HCC associated with HBs antigen (HBsAg)-positive post-hepatitic liver cirrhosis (LC), but this was not related to the history of alcohol intake. In 13 HCC patients of HBsAg-negative alcoholic LC, HBV-DNA integration was not detected in any patient. These findings suggest that HBV does not play a major role in the pathogenesis of HCC in HBsAg-negative alcoholics in Japan.

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