HBO suppressed nitric oxide and apoptosis in articular cartilage defect via up-regulation of hsp 70 expression —In vitro and in vivo study

Hydrostatic pressure induces apoptosis i

Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-α, inducible nitric oxide synthase, p53, c-myc, and bax-α, and suppression of bcl-2

✍ Najmul Islam; Tariq M. Haqqi; Karl J. Jepsen; Matthew Kraay; Jean F. Welter; Vic 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB 👁 1 views

## Abstract Hydrostatic pressure (HP) is thought to increase within cartilage extracellular matrix as a consequence of fluid flow inhibition. The biosynthetic response of human articular chondrocytes to HP in vitro varies with the load magnitude, load frequency, as well as duration of loading. We f