Hb questembert is due to a base substitution (T→C) in codon 131 of the α 2-globin gene and has an α-thalassemia biosynthetic ratio
✍ Scribed by J. Rocheite; R. Barnetson; S. L. Thein; B. Varet; F. Valensi
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 215 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
To the Editor: Trisomy 21 Down's syndrome (DS) predisposes to the development of acute lymphocytic and non-lymphocytic leukemias [ 1-31, acute myelofibrosis [4], and a transient myeloproliferative disorder of newborns [Z]. The hypereosinophilic syndrome (HES) is a myeloproliferative Department of Medicine, The Memorial Hospital, Brown universiv, pawtuck&, Rho& /s/and disorder characterized by long-term idiopathic eosinophilia, hepatosplenomegaly , and organ infiltration with eosinophils [5]. The present report describes the first patient with trisomy 21 DS who developed HE.3 and suggests that trisomy 21 may contribute to the evolution of HES.