✦ LIBER ✦
Hb Q-Thailand-Hb H disease in a chinese living in Geneva, Switzerland: Characterization of the variant and identification of the two α-thalassemic chromosomes
✍ Scribed by P. Beris; P. Huber; P. A. Miescher; J. B. Wilson; A. Kutlar; S. S. Chen; Dr. T. H. J. Huisman
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 402 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Data on a 24-year-old Chinese male with Hb Q-Thailand-Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse-phase high-performance liquid chromatography. Gene mapping analyses identified the a-thalassemia-2, which is associated with the a-Q chain, as caused by a 4.2-kb deletion involving the a 2 globin gene, while the a-thalassemia-1 anomaly was the common Southeast Asian type in which part of the ${, the $a, and the a 2 and a1 globin genes are deleted,