✦ LIBER ✦

Harvesting peripheral blood stem cells from healthy donors on 4th day of cytokine mobilization

✍ Scribed by Sang Kyun Sohn; Jong Gwang Kim; Woo Jin Sung; Dong Hwan Kim; Jang Soo Suh; Kun Soo Lee; Kyu Bo Lee

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 75 KB
Volume: 18
Category: Article
ISSN: 0733-2459
DOI: 10.1002/jca.10075

No coin nor oath required. For personal study only.

✦ Synopsis

A pilot study was conducted to evaluate the efficacy of harvesting peripheral blood stem cells from normal healthy donors on day 4 after mobilization with G-CSF at 10 microg/kg for 4 days or a sequential combination of GM-CSF at 10 microg/kg for 2 days and G-CSF at 10 microg/kg for 2 more days. Harvesting over the target dose (>4 x 10(6) kg) of CD34+ cells based on the lst leukapheresis performed on day 4 was possible from 7 (53.8%) out of 13 donors. The 7 matched recipients all exhibited early engraftment, except for one who experienced transplant-related mortality, and no differences were observed with the recipients transplanted with stem cells harvested after a 5-6-day growth-factor (GF) treatment. Accordingly, harvesting from normal healthy donors on day 4 after mobilization treatment with a GF was found to be feasible for allogeneic peripheral blood stem cell transplantation and more economical in terms of the cost of the GF and the donor's commitment.

📜 SIMILAR VOLUMES

Harvesting peripheral blood progenitor c

Harvesting peripheral blood progenitor cells from healthy donors: retrospective comparison of filgrastim and lenograstim

✍ Massimo Martino; Giuseppe Console; Giuseppe Irrera; Ida Callea; Antonia Condemi; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB

Mobilization of CD34+ into peripheral blood is attained by either glycosylated (lenograstim) or non-glycosylated recombinant G-CSF (filgrastim). 101 donors, 57 males, median age 42 years (range 16-63) entered this retrospective study. Group I (55 cases) received filgrastim and group II lenograstim s

Large-volume leukapheresis using femoral

Large-volume leukapheresis using femoral venous access for harvesting peripheral blood stem cells with the Fenwal CS 3000 Plus from normal healthy donors: Predictors of CD34+ cell yield and collection efficiency

✍ Sang Kyun Sohn; Jong Gwang Kim; Yeo Soo Chae; Dong Hwan Kim; Nan Young Lee; Jang 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB 👁 1 views

## Abstract The current paper reports on the predicting factors associated with satisfactory peripheral blood stem cell collection and the efficacy of large‐volume leukapheresis (LVL) using femoral vein catheterization to harvest PBSCs with Fenwal CS 3000 Plus from normal healthy donors for allogen