✦ LIBER ✦

Hapten-specific tolerance: unresponsiveness in the t celldepleted population

✍ Scribed by J. A. Hamilton; J. F. A. P. Miller

Book ID: 102159628
Publisher: John Wiley and Sons
Year: 1973
Tongue: English
Weight: 356 KB
Volume: 3
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830030716

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✦ Synopsis

Abstract

Complete and specific suppression of the anti‐NIP [(4‐hydroxy‐5‐iodo‐3‐nitro‐phenyl)acetyl] indirect plaque‐forming cell response to NIP‐fowl IgG was obtained in mice by pretreatment with NIP‐coated syngeneic erythrocytes. The complete suppression occurred within 5 to 7 days and was evident after adoptive transfer of spleen cells into irradiated mice. The state of unresponsiveness was reversed, not by thymus cells, but by supplementing with T cell‐depleted normal spleen cells. This suggests that the unresponsiveness occurred at the level of the B lymphocyte population.

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