Hapten-induced paralysis. I. Evidence for the persistence of hapten-specific immunocompetent B lymphocytes in specifically paralyzed mice

✍ Scribed by Eva Gronowicz; A. Coutinho; O. Sjöberg

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 442 KB
• Volume: 4
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830040314

✦ Synopsis

Abstract

Injection of 3,5‐dinitro‐4‐hydroxy‐phenacetyl (NNP) azide induced specific unresponsiveness, as judged by the failure of pretreated mice to respond to NNP‐HRC (horse red blood cells), but not to HRC. The unresponsiveness of the NNP azide‐treated mice was not broken by incubating lymphocytes in vitro together with NNP‐HRC. Injection of the nonreactive hapten, NNP‐ϵ‐aminocaproic acid, also induced specific unresponsiveness when measured in vivo, but cells from such animals did respond normally in vitro. Spleen cells from mice treated with NNP azide contained a higher number of background PFC to NNP and NIP as compared to untreated controls.