Haplotypes covering the TNFSF10 gene are associated with bronchial asthma
β Scribed by Markus Weckmann; Matthias Volkmar Kopp; Andrea Heinzmann; Joerg Mattes
- Book ID
- 110895502
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 183 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0905-6157
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IL10 is an anti-inflammatory cytokine that has been found to have lower production in macrophages and mononuclear cells from asthmatics. Since reduced IL10 levels may influence the severity of asthma phenotypes, we examined IL10 singlenucleotide polymorphisms (SNPs) for association with asthma sever
## Abstract Asthma is an airway hyperresponsive disease characterized by the expression of multiple inflammatory genes, including cytokines. InterleukinβI and interleukinβ10 (ILβ1 and ILβ10) are cytokines that might play a role in the process of inflammation and are therefore considered to be invol