Haplotype Variation and Linkage Disequilibrium in 313 Human Genes
โ Scribed by Stephens, J. C.
- Book ID
- 119973916
- Publisher
- American Association for the Advancement of Science
- Year
- 2001
- Tongue
- English
- Weight
- 298 KB
- Volume
- 293
- Category
- Article
- ISSN
- 0036-8075
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Haplotypes of the insulin receptor gene were resolved in parents from Scandinavian nuclear families by studying the segregation of seven restriction fragment length polymorphisms (RFLPs). Of 97 unrelated parents, 41 had non-insulin-dependent diabetes mellitus (NIDDM). Considerable linkage disequilib
## Abstract The characterization of linkage disequilibrium (LD) is applied in a variety of studies including the identification of molecular determinants of the local recombination rate, the migration and population history of populations, and the role of positive selection in adaptation. LD suffer