Haplotype sharing test maps genes for familial cardiomyopathies
โ Scribed by PA van der Zwaag; JP van Tintelen; F Gerbens; JDH Jongbloed; LG Boven; JJ van der Smagt; WP van der Roest; IM van Langen; H Bikker; RNW Hauer; MP van den Berg; RMW Hofstra; GJ te Meerman
- Book ID
- 110889078
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 642 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0009-9163
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It is well recognized that multiple genes are likely contributing to the susceptibility of most common complex diseases. Studying one gene at a time might reduce our chance to identify disease susceptibility genes with relatively small effect sizes. Therefore, it is crucial to develop statistical me
## Abstract The present study introduces new Haplotype Sharing Transmission/Disequilibrium Tests (HSโTDTs) that allow for random genotyping errors. We evaluate the type I error rate and power of the new proposed tests under a variety of scenarios and perform a power comparison among the proposed te