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Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease

✍ Scribed by Greg T. Sutherland; Gerhard A. Siebert; Jeremy R. B. Newman; Peter A. Silburn; Richard S. Boyle; John D. O'Sullivan; George D. Mellick

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
905 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the __PARK__11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender‐matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians. Β© 2008 Movement Disorder Society

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