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Haplotype analysis of the Mexican frameshift Cd 11 (−T) and −28 A→C β-thalassemia alleles

✍ Scribed by Perea, Francisco J.; Esparza, M. Amparo; Villalobos-Arambula, Alma Rosa; Ibarra, Bertha; Old, John M.

Book ID: 101216875
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 181 KB
Volume: 51
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199603)51:3<240::aid-ajh11>3.0.co;2-k

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✦ Synopsis

Theorlglnsofthe -28A-CandframeshlftCd 11 -T(FsCd 11 -T)alleleswerelnvestigated by p-globln cluster haplotype analysis. These alleles were found in a Mexican mestizo family with p-thalassemia (p-thal). The -28 A-4 mutation was descrlbed prevlously In Kurdish Jews linked to the most common haplotype In the world (+----++), the same haplotype observed In this Mexican family. Therefore, It Is not possible to assess a new origin of the -28 A-C mutation In our population. The Fs Cd 11 -T allele, not reported to date In any other populations, was linked to the -++--+haplotype (sixth In frequency In the world). This haplotype has not been reported in association with any 0-thal mutant, suggesting a Mexican origin for the Cd 11 -1 mutation. o 1988 Wliey-Lirr. inc.

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