Familial hypercholesterolemia (FH) results from mutations in the low density lipoprotein (LDL) receptor gene. It has been shown that restriction fragment length polymorphisms (RFLPs) associated with this gene may be used for family and population studies. The present investigation is a population-ba
Haplotype analysis at the low density lipoprotein receptor locus in normal and familial hypercholesterolemia Norwegian subjects
✍ Scribed by Olaug K. Rødningen; Trond P. Leren; Oddveig Røsby; Serena Tonstad; Leiv Ose; Kare Berg
- Book ID
- 115091430
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 699 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0009-9163
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Heterozygous familial hypercholesterolemia (FH) is a relatively common autosomal dominant disorder, which is characterized by elevated plasma concentrations of low density lipoprotein (LDL) cholesterol and early coronary heart disease. FH results from mutations in the gene encoding the LDL receptor