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Haploinsufficient and predominant expression of multiple endocrine neoplasia type 1 (MEN1)-related genes, MLL, p27Kip1 and p18Ink4C in endocrine organs

✍ Scribed by Ryo Taguchi; Masanobu Yamada; Kazuhiko Horiguchi; Takuya Tomaru; Atsushi Ozawa; Nobuyuki Shibusawa; Koshi Hashimoto; Shuichi Okada; Tetsurou Satoh; Masatomo Mori

Book ID: 116302526
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 695 KB
Volume: 415
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2011.10.077

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Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in parathyroids, enteropancreatic endocrine tissues, anterior pituitary, and other tissues. The gene for MEN1 has recently been cloned and shown to code for a 610-amino acid protein of enigmatic func