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Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice

✍ Scribed by Namiko Yamashita; Motomi Osato; Liqun Huang; Masatoshi Yanagida; Scott C. Kogan; Masayuki Iwasaki; Takuro Nakamura; Katsuya Shigesada; Norio Asou; Yoshiaki Ito

Book ID: 108673476
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 626 KB
Volume: 131
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2005.05793.x

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## Abstract Three patients diagnosed with acute myeloid leukemia (AML) with reciprocal 21q22/__RUNX1__(__AML1__) translocations involving chromosomes 1 and 4 were studied. Three novel __RUNX1__ translocation partner genes on 1q21.2 (__ZNF687__), 1p35 (__YTHDF2__), and 4q31.3 (__SH3D19__) were ident