Handbook of Statistical Genetics (Balding/Handbook of Statistical Genetics, Third Edition) || Cancer Genetics

✍ Scribed by Balding, D. J.; Bishop, M.; Cannings, C.

• Publisher: John Wiley & Sons, Ltd
• Year: 2008
• Weight: 168 KB
• Edition: 3
• Category: Article
• ISBN: 0470058307
• DOI: 10.1002/9780470061619.ch39

✦ Synopsis

Cancers result from an accumulation of inherited and somatic mutations yielding cells that have acquired the necessary characteristics for unregulated growth. The development of the tumour can be viewed as an evolutionary process, involving several classes of genes in tumour initiation and progression.

This chapter provides an overview of the development of cancer genetic models. The earlier mathematical and statistical models based on population and cancer family observations, are followed by evolutionary models applied to molecular genetic sequence data.