Handbook of experimental pharmacology, volume 28, part 2, concepts in biochemical pharmacology. Edited by B. B. Brodie and J. R. Gillette. Springer-Verlag New York, Inc., 175 Fifth, Ave., New York, NY 10010, 1971. xx + 778 pp. 16.5 × 25 cm. Price $75.00

✍ Scribed by William F. Bousquet

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 257 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600611146

✦ Synopsis

The presence of indicated by a of a phenolic group in the molecule. a phenolic hydroxyl group was also broad absorDtion band at 350& 3200 cm.-' in the IR spectrum. A lack of peaks at 1480 and 940 cm.-' in the IR spectrum was suggestive of the absence of the methylenedioxy function in the molecule, which was confirmed by a negative Labat's test and by a lack of absorption in the area of 6 p.p.m. in the NMR spectrum.

An N M R spectrum of fagaronine (Ia) in dimethyl sulfoxide, with tetramethylsilane as the internal standard, showed peaks for -N+-CH3 (6 in p.p.m., singlet at 5.1 I), three -OCH3 (singlets at 4.24, 4.11, and 4.04), 6-position proton (singlet at 9.97), protons at positions I I and 12 (doublets centered at 8.86, J =