[Handbook of Experimental Pharmacology] Protein-Protein Interactions as New Drug Targets Volume 186 || An Oncogenic Hub: β-Catenin as a Molecular Target for Cancer Therapeutics

✍ Scribed by Klussmann, Enno; Scott, John

• Book ID: 111676291
• Publisher: Springer Berlin Heidelberg
• Year: 2008
• Tongue: German
• Weight: 217 KB
• Edition: 2008
• Category: Article
• ISBN: 3540728430
• DOI: 10.1007/978-3-540-72843-6_11

✦ Synopsis

Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.