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✦ LIBER ✦

[Handbook of Experimental Pharmacology] Neurotrophic Factors Volume 220 || NGF, BDNF, NT3, and NT4

✍ Scribed by Lewin, Gary R.; Carter, Bruce D.

Book ID: 121706017
Publisher: Springer Berlin Heidelberg
Year: 2014
Tongue: German
Weight: 158 KB
Edition: 2014
Category: Article
ISBN: 3642451063
DOI: 10.1007/978-3-642-45106-5_1

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✦ Synopsis

The discovery of nerve growth factor (NGF) was a seminal event in history of research in developmental neurobiology. The further discovery that NGF was just one of a family of structurally similar growth factors, neurotrophins, provided important insights into the way nerve cells communicate, during development of the nervous system, and in neuroplasticity, memory, and learning in the adult nervous system. Four neurotrophins, NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4), regulate a wide variety of neural functions, acting upon p75NTR, TrkA, TrkB, and TrkC receptors.

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