[Handbook of Experimental Pharmacology] Drug Transporters Volume 201 || Multidrug Resistance Proteins (MRPs, ABCCs): Importance for Pathophysiology and Drug Therapy

✍ Scribed by Fromm, Martin F.; Kim, Richard B.

• Book ID: 119937795
• Publisher: Springer Berlin Heidelberg
• Year: 2010
• Tongue: German
• Weight: 238 KB
• Edition: 2011
• Category: Article
• ISBN: 3642145418
• DOI: 10.1007/978-3-642-14541-4_8

✦ Synopsis

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.