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[Handbook of Experimental Pharmacology] Antiviral Strategies Volume 189 || Approaches for the Development of Antiviral Compounds: The Case of Hepatitis C Virus

✍ Scribed by Kräusslich, Hans-Georg; Bartenschlager, Ralf

Book ID
121083764
Publisher
Springer Berlin Heidelberg
Year
2009
Tongue
English
Weight
624 KB
Edition
1
Category
Article
ISBN
3540790861

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✦ Synopsis

A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.

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