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Hammerhead ribozymes directed against cyclin E and E2F1 as tools to prevent in-stent restenosis

✍ Scribed by Herdeg, Christian; Oberhoff, Martin; Schroeder, Stephen; Kuhn, Anne; Kandolf, Reinhard; Seipel, Ludger; Grassi, Gabriele

Book ID
123075457
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
191 KB
Volume
41
Category
Article
ISSN
1558-3597

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## Abstract ## Background Anti‐proliferative drugs released from endo‐vascular stents have substantially contributed to reduce in‐stent restenosis rates in coronary arteries bearing single primary lesions by down‐regulating coronary smooth muscle cell (CSMC) growth. However, the considerably lower