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Hammerhead Ribozyme-Mediated Inhibition of Telomerase Activity in Extracts of Human Hepatocellular Carcinoma Cells

✍ Scribed by Yoshiyuki Kanazawa; Kazuyoshi Ohkawa; Keiji Ueda; Eiji Mita; Tetsuo Takehara; Yutaka Sasaki; Akinori Kasahara; Norio Hayashi

Book ID
115578883
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
241 KB
Volume
225
Category
Article
ISSN
0006-291X

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## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti