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Halogen substituted derivatives of acetylcholine as inhibitors of choline acetyltransferase

✍ Scribed by D. Morris; D.S. Grewaal

Book ID
118934804
Publisher
Elsevier Science
Year
1969
Tongue
English
Weight
215 KB
Volume
8
Category
Article
ISSN
0024-3205

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The uptake of choline into cholinergic neurons for acetylcholine (ACh) synthesis is by a specific, high-affinity, sodium- and temperature-dependent transport mechanism (HAChU). Of several quaternary quinuclidinol derivatives tested, the N-allyl derivative proved to be most potent. Though the methyl,